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Enhanced angiogenesis refers to the process of forming new blood vessels, which leads to improved vascularization of tissues and facilitates healing

This results in release of 4EB-P1 from eIF4E which can then direct ribosomes to the cap structure of mRNAs to promote cap-dependent translation, one of major functions of the IGF-1R axis (Tognon and Sorensen, 2012)

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The lung mucosa is another site of protein citrullination leading to RA development, promoted by microbial infection or dysbiosis and the inhalation of pollutants such as tobacco smoke or other pollutants (168, 169)