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[DOI] [PMC free article] [PubMed] [Google Scholar] 20.Hong Y., Downey T., Eu K

Understanding the role of histone deacetylase and their inhibitors in neurodegenerative disorders: current targets and future perspective

Further evidence shows that physical activity promotes neural resilience by upregulating brainderived neurotrophic factor (BDNF) and supporting corticostriatal circuitry [114, 115, 116]

The CDR highlights that many seemingly disparate chronic conditionsfrom neurological disorders to chronic pain and fatigueshare a common final pathway of metabolic dysfunction: a cell defensively stuck in survival mode

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This theory was proposed after it was discovered that the drug chlorpromazine had antipsychotic properties ( However, antipsychotic drugs tend to alleviate positive symptoms more than negative symptoms ( Metabolism of dopamine has been suggested to be a prominent producer of reactive oxygen species in the brain ( 2 O 2 which when in the presence of iron or oxygen can form the more active hydroxyl radical (