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Montagnani M, Bottalico L, Potenza MA, et al

Under these conditions, the enzyme -glutamylcysteine ligase continues to produce large quantities of -glutamylcysteine, which is converted by -glutamyl cyclotransferase into 5-oxoproline (Figure 1C)
This causes increased neuroinflammation in human brain vascular pericytes (Table 1), which further leads to neurovascular unit disruption and immune cell transmigration across the BBB (Niu et al., 2019

This phenomenon may be particularly relevant in PD, as the high content of polyunsaturated fatty acids in neuronal membranes, combined with the oxidative environment created by dopamine metabolism and iron accumulation, makes these cells especially susceptible to ferroptotic damage [226,227,228,229]

Not particularly aimed at removing scar (in fact, they are not specifically targeted), these injections actually can help to light dark acne scarring and improve skin clarity

FIGURE 7 Endothelial cell aging is closely associated with the progression of various diseases, potentially exacerbating the senescence of surrounding cells and worsening pathological processes (Hwang et al., 2022)
