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Both GS-PG conjugates are transported by MRP1 in vitro with relatively high affinity ( K m app 0.9 and 1.4 m, respectively), and GSH conjugation and subsequent MRP1-mediated efflux of these PG conjugates protects cells from the cytotoxic effects of their parent PGs

Methylglyoxal-derived advanced glycation endproducts accumulate in multiple sclerosis lesions

Soft Matter Phys

Transactivation of NRF2 in KO livers was further supported by constitutive induction of NRF2 target genes, including Gclc , metallothionein I ( Mt1 ) and heme-oxgenase 1 ( Hmox1) (Fig

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Furthermore, melatonin supports neuronal survival by preserving mitochondrial function, which is essential for cellular energy metabolism and apoptosis regulation