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Injectable Vitamin B12 30ml (max 4 per order) 40.80 Ex Tax: 34.00 Availability: In Stock Product Code: ISHI001 30ml vitamin B12 as hydroxocobalamin for injections 1ml contains 1000g Suitable for intramuscular injections into the gluteus medius (buttocks) Contains only hydroxocobalamin in distilled water Suitable for vegetarians and vegans Vitamin B12 is unique because it is the only vitamin that cannot be obtained from plants or sunlight

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10.1021/acs.jmedchem.7b01422 8 BachD.-H.KimD.BaeS

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The complete side effect frequency breakdown from Phase 2 trials: Very Common (20%+ of patients at 12mg dose) Nausea: 28% Typically mild to moderate, peaks weeks 4-8, usually resolves by week 12 Diarrhea: 24% Usually transient (1-3 weeks), rarely severe Constipation: 21% Paradoxically coexists with diarrhea in different patients Common (10-20% of patients) Vomiting: 17% Decreased appetite: 16% (beyond therapeutic effect) Injection site reactions: 14% Fatigue: 13% Dyspepsia (indigestion): 12% Headache: 11% Uncommon (2-10% of patients) Abdominal pain: 8% Dizziness: 7% Gastroesophageal reflux: 6% Hypoglycemia in diabetics on other medications: 5% Increased heart rate (average 2-4 bpm): 4% Hair thinning/loss: 3% (typically temporary) Rare but Serious (Under 2%) Pancreatitis: 0.3% (3 cases out of 1,032 patients, all resolved with discontinuation) Gallbladder events: 1.4% (expected with rapid weight loss regardless of method) Acute kidney injury: 0.7% (all cases associated with severe dehydration) KEY TAKEAWAY: About 30% experience meaningful nausea in the first 4-8 weeks