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Many possible forms of channel modulation involving the N-terminal region have been described: (1) irritating agonists and electrophiles (isocyanates, cinnamaldehyde, garlic diallyl disulfide, acrolein) can chemically react with primary amines and cysteines (Bahia et al., 2016

This interference might lead to false-negative results or altered protein behavior

Recent work has shown that human ZIP4 is able to transport Cu (II) with micromolar affinity when expressed in oocytes (Antala & Dempski, 2012)

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