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29 ChinnusamyV.ZhuJ

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143B cells were plated in 12-well plates at a density of 3 10 5 cells/well and subsequently cultured for 12 h

One such example is the neurological epigenetic disease called Angelman syndrome, that results from epigenetic silencing of the paternal UBE3 allele combined with a mutation or deletion in the maternal UBE3 allele, resulting in loss of E3 ubiquitin ligase, leading to multiple neuronal defects like epilepsy, ataxia, etc

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