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The National Cancer Institute's Common Terminology Criteria for Adverse Events (CTCAE) is a standard evaluation of possible adverse reactions of hundreds of drugs used in cancer treatment, and it is the most widely used CIT severity grading standard [9]

Although numerous studies support an association between gut microbiota dysbiosis and ASD, the reproducibility of these findings across different cohorts remains limitedparticularly in alpha and beta diversity analyses, which frequently yield contradictory results

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