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Alternatively, peptide bond surrogates can have protease inhibitor activity at the substrate cleavage site, and therefore offer a fundamental strategy for understanding protease enzyme activity, especially if isosteres can imitate the transition state of bond degradation (hydrolysis)
10.1016/j.it.2020.07.004 Trends Immunol
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J Ethnopharmacol 129(2):142166 Jainu M, Devi CS (2006) Antiulcerogenic and ulcer healing effects of Solanum nigrum (L.) on experimental ulcer models: possible mechanism for the inhibition of acid formation

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Maurya, Anil Kumar, et al
