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Several experimental therapies for CIPN prevention have reached the clinical stage of testing

Insulin-like growth factor 1 and growth hormone in chronic liver disease

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Compounds with balanced molecular weight, moderate topological polar surface area, and optimal lipophilicity exhibited more favorable docking behavior

Furthermore, oxidative stress can impede the nucleoplasmic translocation of pancreaticoduodenal homeobox factor 1 (PDX-1), impair energy metabolism, and reduce insulin production and release (Duni et al., 2019)

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