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veterans with T2DM, reporting that metformin therapy lasting more than 4 years significantly decreased the risk of developing both PD and AD (Shi et al., 2019)

These changes may include increasing arterial stiffness, reduced elasticity, impaired function of the blood-vessel lining, chronic inflammation, and the development of atherosclerotic plaque

Nevertheless, sulphasalazine has been demonstrated to be an effective treatment in cancer models, by inhibiting xCT to activate ferroptosis 232,233 and restore sensitivity to chemotherapy

doi: 10.1136/bmjopen-2018-022188 108 WangWLoACY

Post-Traumatic Stress Disorder Post-traumatic stress disorder (PTSD) is an anxiety disorder that occurs after a person has personally experienced or witnessed a dangerous and life-threatening event

Invading white blood cells secrete pro-inflammatory factors, which trigger reactive response of neural parenchymal cells, most notably reactive astrogliosis and microgliosis