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The standard escalation protocol increases your dose in stages over 16 to 20 weeks, giving your body time to adapt to each level before moving to the next

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In some rare cases, such as when a tophus is infected or when its location is causing major disability, surgical removal may be considered

Curr Med Res Opin 20(8):13211327 Ferretti G, Bacchetti T, Sahebkar A (2015) Effect of statin therapy on paraoxonase-1 status: a systematic review and meta-analysis of 25 clinical trials