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Description

Optimization of orally bioavailable enhancer of zeste homolog 2 (EZH2) inhibitors using ligand and property-based design strategies: identification of development candidate (R)-5,8-dichloro-7-(methoxy(oxetan-3-yl)methyl)-2-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3,4-dihydroisoquinolin-1(2H)-one (PF-06821497)

10.1542/pir.32-8-341 72 LeeH

The data are presented as Mean SD, with n = 6

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Your doctor may decide not to use IV metronidazole if you have uncontrollable high blood pressure (resistant hypertension), congestive heart failure, or significant fluid retention