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doi: 10.1016/S0140-6736(14)60460-8
PE-22-28 inhibits TREK-1 with an IC50 of 0.12 nM, as determined by electrophysiology in HEK293 cells expressing human TREK-1
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However, CagriBB has equivalent potency to Cagri, in CRE-reporter assays in mammalian cells expressing AMY 3 Rs (Supplementary Table 4), suggesting there is negligible impact of this rotamer difference
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