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Interactions of zinc-and redox-signaling pathways

Zhang et al., 2022

The four M8-03 mutants were unable to restore the doxorubicin resistance observed in FlpIn 293 cells overexpressing wild-type MRP1 (Supplementary Fig

For those TTC: Glutathione levels decrease as we age, negatively impacting sperm and egg health

We found no differences between the preparation conditions tested nor an effect of time to deproteinization on stability of total GSH, suggesting that use of either heparin or EDTA during sample collection can prevent enzymatic degradation of GSH when samples are stored at 80 o C

It has also been observed a correlation between high levels of GSTP1-1 in the brain and medical intractability, suggesting that the enzyme may contribute to resistance to antiepileptic drug treatment 62