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Gram-negative bacteria or their products can be transferred from the intestinal lumen to the circulatory system, causing an inflammatory response in the liver and inducing the necrosis of hepatocytes (3)

[DOI] [PMC free article] [PubMed] [Google Scholar] 41.Mattson M.P

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Regarding cytotoxicity, our results on MCF-7 cells are consistent with the pioneering findings of Kulkarni et al

Oxidative stress is the disturbance in the balance between the generation of free radicals, such as reactive oxygen species (ROS) and reactive nitrogen species (RNS), and antioxidant defenses, and can cause oxidative damage to diverse cellular components, such as membranes, proteins, and DNA