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10.3390/ijms242216112 58 KataokaK.HaradaA.NagasakiY

This is believed to lead to activation of the MPTP due to oxidative stress and depletion of ATP, resulting in apoptosis or necrosis, dependent on the severity of mitochondrial dysfunction and the degree of ATP loss (Visentin et al., 2020

As a result, many people suffer from chronic, systemic inflammation

Subsequently the metabolic pathways diverge, producing many intermediates

Aging (2020) 12(2):111427