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Furthermore, metformin has demonstrated potential in reducing the frequency of kidney disease in diabetic individuals by managing reducing oxidative stress and restoring biochemical alterations in kidney tubules, thereby averting tubular damage [24]

Because standard gastrointestinal absorption of B12 is highly complex and easily disrupted by age, low stomach acid, medications, and chronic inflammation, therapeutic dosing often needs to be significantly higher than the standard Recommended Daily Allowance (RDA) of 2.4 mcg

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