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Molecular Mechanisms of Cardiomyocyte Death in Drug-Induced Cardiotoxicity

2.3 Selenium (se) Selenium (Se), an essential trace element, functions through selenoproteins including glutathione peroxidase (GSH-Px) and thioredoxin reductase (TxRs), which serve as pivotal antioxidants (46)

Our results displayed that prolonged exogenous IGF-1 or IGF-1 overexpression downregulated the p53/progerin pathway to prevent hepatocyte premature senescence

[DOI] [PMC free article] [PubMed] [Google Scholar] 63.Hall KE, Proctor DD, Fisher L, Rose S

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5i, Supplementary Fig
