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Exposure to opioids such as oxycodone results in a greater than six-fold increase in expression in rat liver of glutathione S-transferase A-5, an enzyme that catalyzes conjugation of glutathione to toxic substances, while the expression of the cytochrome enzyme CYP3A2 is decreased seven-fold [24]

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Collagen is the "glue" that holds your joints, tendons, and skin together

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Antioxidants 11(8):118

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Concentrations of glutamate released following spinal cord injury kill oligodendrocytes in the spinal cord

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In the central nervous system (CNS), both cell replacement and tissue engineering strategies are being vigorously pursued to facilitate regeneration of native tissue and/or to directly restore lost function based on permanent structural integration

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Other conditions were optimised and are described later

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