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In the case of NTRK (1 and 3), expression is usually so intense that moderate, weak, or patchy expression should be considered doubtful because some isoforms of NTRK are expressed in healthy melanocytes and NTRK can be expressed in non-Spitz melanocytic tumors (e.g., blue nevus and deep penetrating nevus) owing to overexpression of ALK via other molecular mechanisms

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