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To illustrate, such a mechanism could lead to the activation of the transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2), as suggested by Ohta (2023), which is known to be involved in oxidative stress responses (Yu et al., 2021) and involves a basic leucine zipper (bZIP) transcription factor

Furthermore, the specific activities of some enzymes that metabolize GSH are high, as in the case of glutathione peroxidase, glutathione reductase, and glutathione Stransferase

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Total ROS was measured following post-hoc Tukeys multiple-comparison test

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In the hypoxic TME, stabilization of HIF-1 not only enhances glycolytic flux through the upregulation of HK2 and PDPK1, but also supports tumor cell motility and invasiveness (77)