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Notably, the addition of carnitine or knockdown of TMLHE did not have marked effects on histone methylation (Extended Data Fig

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[DOI] [PubMed] [Google Scholar] VzquezMeza, H

However, prolonged interactions between T cells and tumors impair Tcell competence, while PGC1 inactivation leads to mitochondrial dysfunction, thereby compromising the immune activity of CD8 + T cells