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These findings were in agreement with in vitro studies using bone tissue cultures in which IGF-I was reported to both inhibit osteoclasts and interfere with osteoblast-derived factors that stimulate existing osteoclasts [59]

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Intriguingly, the EV-HFD exhibited an upregulation in the loading of catalase (CAT) when compared to the adipose tissue-derived EVs from normal chow-fed mice (EV-NC)

Biochemistry 47 , 1114411157 (2008)

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