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Streamlining is the idea underlying IM8

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Inhibition of VGF impairs the formation of glucagon immature secretory granules and compromises glucagon maturation, lead to reduced -cell hypersecretion of glucagon

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Among all the poses from IFD, docked GSSG on C23 represents many polar contacts with several nearby residues on GLRX protein including hydrogen bonding with C83, N55, Y25, G82, P24, T22, and K20 which stabilizes the complex significantly