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Systemic involvement must be addressed by a multidisciplinary team, especially with hepatologists, nephrologists and pulmonologists since there is no parallel between cutaneous manifestations and the involvement of other organs

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Treatment primarily involves managing the symptoms and might include: Hospitalization, often in a specialized unit depending on the organ involvement Systemic corticosteroids to control inflammation Supportive care for affected organs, which might include dialysis for kidney failure or specific interventions for other organ failures Monitoring and managing complications, including infections that can occur due to the impaired immune response It is crucial for individuals to work closely with their healthcare provider to determine the best course of treatment