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We thus here sketch a roadmap for application of multiscale in silico models, suggesting how the power of mathematical and computational modeling methods may augment and illuminate this significant public health problem

PMID 29270101

Fast forward to 2023 and the figure for that group more than tripled, to 16%, with highs in snus use of 34% among 25-34-year-old men, and 23% for women in the same age group