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Cytochrome c binds to apoptotic peptidase-activating factor 1 (APAF-1) and this adaptor platform induces activation of the initiator caspase, caspase-9

VDR also regulates several other genes, in addition to MDM2 , that are targeted by p53 and its protein family, including the cell cycle regulator CDKN1A and several apoptotic effectors [145]

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