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Although several carcinogens were already known at the time (for example, benzo[a]pyrene was isolated from coal tar and demonstrated to be a potent carcinogen in 1933), none were known to be contained in adequate quantities in tobacco smoke

"Nicotine poisoning occurs when nicotine begins to exhibit more dire toxic effects on an individual." The Centers for Disease Control and Prevention (CDC) warns that 50 to 60 milligrams of nicotine is a deadly dose for an adult who weighs about 150 pounds

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Smoking is the act of inhaling and exhaling smoke from burning tobacco or other substances, such as marijuana or e-cigarettes

(unless you want to damage your pipe!)