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Current Addiction Reports, 8 (2), 336346

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The selected IVs were analyzed for associations with other phenotypes using the PhenoScanner 18 , defined as having a history of smoking, currently smoking, and being exposed to tobacco smoke and air pollution in the offspring, to further reduce the possible impact of horizontal pleiotropy on the study

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Therefore, the low plasma uric acid level in smokers is attributed to a reduction of endogenous production