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92 showed in transgenic mice that deficiency in FoxO1, a protein that modulate the expression of genes involved in cell differentiation, DNA damage repair, and oxidative stress, induced a decrease in osteoblasts differentiation and an increase in caspase-3 activity, resulting in these cells apoptosis

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The genetic makeup of the fetus and mother, route of exposure, dose, and duration of exposure will determine the effect, says Dr