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Is secondhand smoke from pipes less harmful than cigarette smoke

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Wang JY, Liu DD, Sun ZW, Ye T, Li JY, Zeng B, et al

NFkappaB regulates p21 expression and controls DNA damage-induced leukemic differentiation

Cai et al., 2009

Figure 1 2.1 The role of p53 in spermatogonia The maintenance of spermatogenesis throughout the males lifetime relies on SSCs, which possess the ability to self-renew and differentiate into committed spermatogonial progenitor cells (SPCs) ( single (A s ), A paired (A pr ) and A aligned (A al ) spermatogonia and can be distinguished by several genes, including Ngn3 , Sox3 , Gfr1 and Plzf ( Gfr1 + cells (mainly A s , A pr , and some A al ) are stem cells that can transform into Ngn3/Sox3 + (mainly A al and some A pr ) committed SPCs