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This study of smoking tells us that looking in the DNA of cancers can provide provocative new clues to how cancers develop and thus, potentially, how they can be prevented. Professor Sir Mike Stratton Joint lead author from the Wellcome Trust Sanger Institute More information * Other participating centres include University of New Mexico Comprehensive Cancer Center, Albuquerque, USA Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea The Francis Crick Institute, London, UK University of Leuven, Belgium Addenbrookes Hospital National Health Service Trust, Cambridge, UK National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan RIKEN Center for Integrative Medical Sciences, Tokyo, Japan Kyoto University Graduate School of Medicine, Kyoto, Japan The University of Tokyo, Minato-ku, Tokyo, Japan University of Cambridge, Cambridge, UK Human Genetics Foundation, Torino, Italy Medical Research Council (MRC)Public Health England (PHE) Centre for Environment and Health, Imperial College London, London, UK Kings College London, MRC-PHE Centre for Environment and Health, London, UK Funding This work was supported by the Wellcome Trust

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A secondary goal of this study was to inform the selection of health conditions and specific statements that, when paired with color graphics depicting the health conditions described in the warning statements, would form new cigarette health warnings for further testing