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Nicotine, which is made naturally by tobacco plants, but can also be synthetically produced, can cause a chemical addiction in people who use tobacco products, such as cigarettes, or nicotine-infused products, such as cartridges for electronic cigarettes

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Intervention study for smoking cessation in diabetic patients: a randomized controlled trial in both clinical and primary care settings

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Secondhand smoke is particularly deadly: It contains twice as much nicotine and 147 times more ammonia than so-called mainstream smoke, leading to close to 1 million deaths annually, 28% of them children