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(New York: Oxford University Press, 2013), 15

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The heat doesnt seem to have a great impact on (nicotine) strength, but the higher heat will tend to sweeten the leaf as some of the sugars become caramelized

Sekhar et al

Cigarette smoke contains over 4,000 chemical compounds (the tar), ranging from carbon monoxide to hydrogen cyanide, and 69 of which are known carcinogens, including arsenic, benzene, and polonium 210