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44 The primary limitation of these studies, however, remain the relatively low number of patients who do develop pancreatic cancer within these cohorts and larger studies with long-term follow-up are ideally needed to elucidate the potential additive effect of smoking on the risk of pancreatic cancer in CP

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Moreover, the modest successes in reducing smoking initiation rates among adolescents during the past two decades have been offset by net increases in initiation among young adults (between 18 and 25 years of age) during the same time period