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But extrapolating data from oral toxicity studies to inhalation exposure is a common practice among regulatory agencies, according to the studys authors

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We chose this approach because it permitted direct quantification of evidence in support of our null hypothesis about disclaimers and allowed for direct comparisons of the effects of disclaimers on offsetting advertising claims

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4 Much less is known about the adverse effects of longterm cigar or pipe smoking

Permit : An official document granting permission to do something, in this case, to sell nicotine products