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A document by British American Tobacco proposed the addition of synthetic nicotine for adjustment of the nicotine/tar ratio in combustible cigarettes.9 However, this plan was deemed unacceptable since synthetic nicotine was only available as a racemic mixture, containing both S -nicotine and R -nicotine at a 50/50 ratio

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A new approach is needed Despite meaningful progress in reducing and denormalizing tobacco and nicotine in American society, its use remains stubbornly persistent