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NRT is considered safe and approved for use in children aged 12 18 years, although the evidence is limited, and it should not be used for longer than 12 16 weeks

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Quality indicators include consistent nicotine delivery, flavor stability, pouch comfort, and moisture control

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In whole-cell recordings, DA neurons in the VTA can be distinguished from other cell types in the nucleus by action potential firing rates, action potential duration, soma diameter and the presence of a prominent hyperpolarization activated current, I h [23]

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