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Plenty of the chemicals in cigarettes are more inherently toxic than nicotine, but since its the main chemical in cigarettes and its also the substance that gets you addicted to tobacco, theres no question that nicotine is the worst substance present in cigarettes

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Immunologic effects Smoking profoundly impacts both innate and adaptive immunity, often aggravating pathological immune responses while suppressing defensive mechanisms [19]

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It is estimated that 65 million packs of cigarettes were smuggled out of Indiana in one year