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Additionally, economic growth has tended to increase the cost of healthcare without a commensurate increase in health sector productivity, a phenomenon known as the Baumol effect (panel 8)

Furthermore, it can be used as an advocacy tool in the fight for tobacco control and prevention of tobacco-related disease

Nevertheless, it is noteworthy that mitochondrial and endoplasmic reticulum impairments, as well as the interaction between these two organelles at the level of mitochondrial-associated membranes, are a frequent mechanism of neurodegeneration and optic neuropathies, particularly through the protein and oxidative stresses they generate, as shown for glaucoma [30]

These messages address the vascular and metabolic harms of nicotine, the dangers of passive exposure, the key pathophysiological pathways leading to CV morbidity and mortality, and the economic burden of nicotine-induced CV disease