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Nicotine-induced sleep disturbances, such as insomnia and REM sleep suppression, have been documented in numerous studies
You may assume that vaping is a safer route than smoking cigarettes, and it is, reducing exposure to some harmful substances found in traditional cigarettes

88.Salicylaldehyde

The Effects of Transdermal Nicotine on Cognition in Nonsmokers with Schizophrenia and Nonpsychiatric Controls
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The outcome was unusual by any measure
