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The NADPH oxidase (Nox) system is a major source of intracellular ROS production in the adult brain and the nicotine withdrawal induced activation of the Nox isoform-Nox-2 expression in microglia, which is believed to be the primary mechanism that results in increased ROS generation and pro-inflammatory response to nicotine withdrawal (131, 132)

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I thought, Mmm, pretty green towel, nice shade of green, beautiful shade of greenand suddenly the color attacked me! Norma asked, How attacked you

Tourangeau R, Yan T, Sun H, Hyland A, Stanton CA