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Description
Since nicotine is quickly absorbed by the digestive tract, clinical signs usually appear within minutes and last for 1 to 2 hours or even 24 hours, depending on the dose

Davis, W

BMC Biotechnol 16(1):81

Medical management involves assessing lung function, treating lung damage from smoking and providing nicotine replacement/addiction therapies

For a while, small quantity of nicotine stimulates the nervous system

Macneil J, Maclean F, Delprado W