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FIGURE 6 FA-mediated downregulation of miR-34a-5p sensitizes APAP-induced hepatotoxicity in vitro To replicate our in vivo observations, we investigated whether treatment with CS ingredients such as DEN and FA (Smith et al., 2000), affected the severity of APAP-induced hepatocellular death by modulating miR-34a-5p expression in vitro using primary hepatocytes

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Molecular alterations in basal cell carcinoma subtypes

These cells can provoke the release of ROS of infected hepatocytes by producing pro-inflammatory (IL-1, IL-6, and TNF-) and profibrotic cytokines (TGF-), which contribute to apoptotic cell death of infected hepatocytes via p53-dependent manner 84

doi: 10.1016/j.taap.2020.115151 97 LeiYZhangEBaiLLiY

Defective p53 post-translational modification required for wild type p53 inactivation in malignant epithelial cells with mdm2 gene amplification