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PVL has one or more areas of homogeneous leukoplakia, which grows slowly and persistently, and tends to become multifocal with exophytic, verrucous, or erythematous areas.22 After a long period, commonly six years, the evolution to carcinoma occurs.23 Areas that are erythematous, verrucous or have papillary surface are characteristic of malignant transformation, and so these areas should have a histopathological confirmation (Fig

Genera found in flue-cured tobacco causing mildew include Aspergillus and Penicillium , among others 15,16