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In addition, future studies should focus on the hallmarks of MDM2p53 axis dysfunction in the chronic progressive liver disease that is strongly associated with HCC initiation and development, which will help to diagnose and treat the HCC at vulnerable early stages

Not the solution CBQ Method Principles Reason 2

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Tobacco smoke condensate increased the phosphorylation of NF-B subunit P65, and colchicine attenuated NF-B phosphorylation in endothelial cells treated with tobacco smoke condensate (Fig