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Nicotine can pass into the human body through smoke inhalation, ingestion, intranasal spray, transdermal patch, topical cream, or enema

doi: 10.1155/2014/943162

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The aerosol liquid in e-cigarettes contains ultrafine particles that can be inhaled deep into the lungs, flavorants such as diacetyl, a chemical linked to serious lung disease, volatile organic compounds and heavy metals, such as nickel, tin and lead, according to the website