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Fraczkiewicz R, Braun W (1998) Exact and efficient analytical calculation of the accessible surface areas and their gradients for macromolecules

Investigators also evaluated the effect of smoking cessation within 6 months on 2-year survival

This could be a positive if familiarity encourages people who smoke to trial the product, but could be a negative if it encourages nicotine-nave persons to initiate

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Patients contributed twice in the experiment (after 10 hours nicotine withdrawal / about 5 minutes after nicotine consumption)