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Exposure to e-cigarette aerosol extracts increases the dose of cisplatin required to induce a 50% reduction in cell growth (IC50) The determination of the concentrations of a drug needed to induce a 50% reduction in cell growth (the half-maximal inhibitory concentration or IC50) is an in vitro measure essential for understanding the pharmacological potency of a drug under specific conditions 37 , and has been reported to be predictive of cancer chemoresistance in patients 38

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